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- DIABETOLOGIA, November 1, 2022, ¡°Timing of physical activity in relation to liver fat content and insulin resistance,¡± by Jeroen H. P. M. van der Velde, et al. © 2022 Springer Nature Switzerland AG. Part of Springer Nature. All rights reserved.

To view or purchase this article, please visit:
https://link.springer.com/article/10.1007/s00125-022-05813-3
[RH] Timing of Physical Activity in Relation to Liver Fat Content and Insulin Resistance

A new study published in the journal Diabetologia found that the time-of-day can influence the health benefits derived from physical activity. The study by Dutch researchers showed that afternoon or evening physical activity was associated with reduced insulin resistance (and thus better blood sugar control) when compared with physical activity throughout the day. Meanwhile, morning physical activity offered no such advantages.

A lack of physical activity combined with sedentary behavior is linked to an increased risk of developing metabolic diseases including type 2 diabetes.

This evidence is further sup-ported by experimental studies showing that frequent interruptions of extended periods of sitting with intervals of standing or light physical activity resulted in lower triacylglycerol levels and reduced blood glucose, indicating an improved blood sugar profile.

This study aimed to investigate the association between the timing of physical activity and health-related metrics like liver fat content and insulin resistance in a middle-aged population.

The study was based on an analysis of results obtained from 775 participants for whom complete data sets were available. This group was 42% male and 58% female, had an average age of 56 years, and had an average body mass index of 26.2 kg/m2.

After adjusting for variables such as age, sex, ethnicity and total body fat, the researchers observed that higher total physical activity was associated with reduced liver fat content as well as reduced insulin resistance.

Most importantly, an association was also found between insulin resistance and the timing of physical activity during the day.

After adjusting for total amount of physical activity, it was found that performing physical activity in the afternoon or evening was linked to reducing insulin resistance, by 18% and 25% respectively, when compared to an even distribution of activity throughout the day.

Furthermore, there was no significant difference in insulin resistance between morning activity and activity spread evenly over the day.

To-date, timing of physical activity is a relatively unexplored field in human biology and the mechanisms underlying the potential benefits of timing of physical activity needs to be considered.

DIABETOLOGIA, November 1, 2022, ¡°Timing of physical activity in relation to liver fat content and insulin resistance,¡± by Jeroen H. P. M. van der Velde, et al. © 2022 Springer Nature Switzerland AG. Part of Springer Nature. All rights reserved.

To view or purchase this article, please visit:
https://link.springer.com/article/10.1007/s00125-022-05813-3